ParkinsonCanadaV1, Main, Exploration, bibRecord, 002B61

Screening for Parkinson's disease with response time batteries: A pilot study

Identifieur interne : 002B61 ( Main/Exploration ); précédent : 002B60; suivant : 002B62

Screening for Parkinson's disease with response time batteries: A pilot study

Auteurs : Andrew M. Johnson [Canada] ; Philip A. Vernon [Canada] ; Quincy J. Almeida [Canada] ; Linda L. Grantier [Canada] ; Rene Singarayer [Canada] ; Mandar S. Jog [Canada]

Source :

BMC Medical Informatics and Decision Making [ 1472-6947 ] ; 2004.

RBID : PMC:518971

English descriptors

KwdEn :
- Aged, Case-Control Studies, Female, Humans, Male, Mass Screening (methods), Middle Aged, Motor Skills (physiology), Neurologic Examination (methods), Ontario, Parkinson Disease (classification), Parkinson Disease (diagnosis), Parkinson Disease (pathology), Pilot Projects, Reaction Time (physiology), Severity of Illness Index.
MESH :
- geographic : Ontario.
- classification : Parkinson Disease.
- diagnosis : Parkinson Disease.
- methods : Mass Screening, Neurologic Examination.
- pathology : Parkinson Disease.
- physiology : Motor Skills, Reaction Time.
- Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Pilot Projects, Severity of Illness Index.

Abstract

Background

Although significant response time deficits (both reaction time and movement time) have been identified in numerous studies of patients with Parkinson's disease (PD), few attempts have been made to evaluate the use of these measures in screening for PD.

Methods

Receiver operator characteristic curves were used to identify cutoff scores for a unit-weighted composite of two choice response tasks in a sample of 40 patients and 40 healthy participants. These scores were then cross-validated in an independent sample of 20 patients and 20 healthy participants.

Results

The unit-weighted movement time composite demonstrated high sensitivity (90%) and specificity (90%) in the identification of PD. Movement time was also significantly correlated (r = 0.59, p < 0.025) with the motor score of the Unified Parkinson's Disease Rating Scale (UPDRS).

Conclusions

Measures of chronometric speed, assessed without the use of biomechanically complex movements, have a potential role in screening for PD. Furthermore, the significant correlation between movement time and UPDRS motor score suggests that movement time may be useful in the quantification of PD severity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC518971

DOI: 10.1186/1472-6947-4-14
PubMed: 15361256
PubMed Central: 518971

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
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<p>Receiver operator characteristic curves were used to identify cutoff scores for a unit-weighted composite of two choice response tasks in a sample of 40 patients and 40 healthy participants. These scores were then cross-validated in an independent sample of 20 patients and 20 healthy participants.</p>
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<p>The unit-weighted movement time composite demonstrated high sensitivity (90%) and specificity (90%) in the identification of PD. Movement time was also significantly correlated (r = 0.59, <underline>p</underline>
 < 0.025) with the motor score of the Unified Parkinson's Disease Rating Scale (UPDRS).</p>
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<p>Measures of chronometric speed, assessed without the use of biomechanically complex movements, have a potential role in screening for PD. Furthermore, the significant correlation between movement time and UPDRS motor score suggests that movement time may be useful in the quantification of PD severity.</p>
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La maladie de Parkinson au Canada (serveur d'exploration)

Screening for Parkinson's disease with response time batteries: A pilot study

Screening for Parkinson's disease with response time batteries: A pilot study

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.